Epigenetic Changes in Psychotherapy of Adolescents With Borderline...
The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brainderived neurotrophic factor BDNF NR3C1 FKBP51 MAOA and...
View ArticleEpigenetic Impact of a Psychotherapeutic Program in Adolescents With Severe...
In this project the investigator proposes to examine the influence of a psychotherapeutic program designed for adolescents with a history of early adverse environmental and psychosocial experiences on...
View ArticleDiagnosis of RSTS Identification of the Acetylation Profiles as Epigenetic...
RubinsteinTaybi syndrome RSTS is a rare and severe congenital developmental disorder characterized by congenital anomalies and intellectual disability with a long term memory deficit. The main...
View ArticleMethylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus...
Type 1 Diabetes Mellitus T1DM is a wellstudied autoimmune disease resulting in insulin deficiency due to selective cell destruction. Epigenetics is a novel field of biology studying the inherited...
View ArticleTreatment of Chronic Itch in Atopic Dermatitis With Topical Naltrexone
To study the etiology and the epigenetic pathways leading to and regulating chronic itch. Similarly to examine the mechanisms underlying skin changes including epigenetic alterations while also testing...
View ArticleProject 1 Diet and Exercise Modulate the Sperm Epigenome in Men
This is a controlled randomized clinical trial to show that diet exercise training and their combination in overweight physically inactive men will alter epigenetic programming to create a "healthy"...
View ArticleHUSH Restriction in HIV Infected Patients
HIV eradication faces a major obstacle that is viral persistence in latent reservoir cells despite antiretroviral therapy. Epigenetic repression plays a central role in viral transgene latency and...
View ArticleEpigenetic Effects in Children With Cow's Milk Allergy Treated With Different...
Lactobacillus GG LGG is able to exert long lasting effects in children with atopic disorders. Nutramigen LGG accelerates tolerance acquisition in infants with cow's milk allergy. The mechanisms of...
View ArticleEarly Origins of Allergy and Asthma
Birth cohort study with recruitment during pregnancy to determine prenatal and perinatal conditions as well as genetic and epigenetic factors that participate in the early setting of immune responses...
View ArticleEpigenetic and Genetic Effects in Cancer Patients Analysis Pre and After...
The prognosis in cancer patients has improved over the years. Survivor rates have increased significantly and paternity has become an important concern in more than 50 of young male survivors. Sperm...
View ArticleBiomarker Study to Evaluate Correlations Between Epigenetic Aging and NAD...
This is a single center prospective study to evaluate correlations between epigenetic aging as measured via DNA methylation and NAD levels in healthy volunteers.
View ArticleEpigenetic Changes in Hepatocellular Carcinoma
Hepatocellular carcinoma HCC is the most common type of liver cancer its survival rate ranks only second to lung cancer and it is a severe threat to human health. In Egypt HCC constitutes a significant...
View ArticleRehabilomics Study in Stroke Patients After Robotic Rehabilitation
Stroke is associated with disability and impaired quality of life. Persistent motor impairment is common with incomplete recovery of motor function after rehabilitation mainly in the upper limbs UL....
View ArticleImmune Resistance Interrogation Study
This is a prospective research study which will include patients who have progressed on immunotherapy as their most recent line of therapy. This study aims to characterize whether patients who fail to...
View ArticleHuman Sperm Epigenetics in Embryonic Development.
A total of 60 men 40 with a history of infertility and treatment with assisted reproduction and 20 infertile controls achieving conception naturally will be asked to provide at least one semen sample...
View ArticleEpigenetic Changes in Head and Neck Cancer
With this study the investigators will investigate the epigenetic changes which may contribute to the development of head and neck squamous cell carcinomas.
View ArticleRadicava Edaravone Findings in Biomarkers From ALS REFINEALS
REFINEALS is a prospective observational longitudinal multicenter study designed to identify biomarkers to serve as quantifiable biological nonclinical measures of Edaravone effects in ALS. Epigenetic...
View ArticleGenetics and Genomics of Aspirin Exacerbated Respiratory Disease AERD
Aspirin Exacerbated Respiratory Disease AERD is a relatively homogeneous disease characterized by adultonset severe asthma development of noncancerous growths in the nasal canal i.e. nasal polyps and...
View ArticleGenetic and Epigenetic Risk of T2D in the UAE
T2D is a global public health crisis and a threat to socioeconomic development of all nations particularly in developing countries. Countries in the Gulf region including the UAE have some of the...
View ArticleCognitive Remediation Therapy in Schizophrenia Effects on Epigenetics
This study is a randomised and controlled trial that aims to investigate whether Cognitive Remediation Therapy CRT can modulate epigenetic mechanisms by changing methylation levels of BDNF gene in...
View ArticleEpigenomewide Association Study in PAH Patients
To identify epigeneticsensitive modifications and novel biomarkers linked to pathogenesis of pulmonary arterial hypertension PAH we will perform the first study analyzing differentiallymethylated...
View ArticleEpigenetics of TNBC in Overweight and Obese Hispanic & NonHispanic White Women
A key tenet of this project is that of reaching translational human diagnosis and biomarker end points. To lay a foundation and make progress towards these translational goals investigators will...
View ArticleCADASIL Registry Study
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy CADASIL and related...
View ArticleCerebral Small Vessel Disease Registry Study
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Small Vessel Disease CSVD and in a prospective multicenter study to assess the clinical genetic and...
View ArticleTreatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone
Purpose To study the etiology and the epigenetic pathways leading to and regulating chronic itch. Similarly to examine the mechanisms underlying skin changes including epigenetic alterations while also...
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